| abstract |
The present invention discloses a novel tricyclic compound represented by formula (1.0), a prodrug thereof, or a pharmaceutically acceptable salt or solvate of the compound or prodrug thereof. The compounds of the present invention or prodrugs thereof are useful for inhibiting fanesyl protein transferase. Also disclosed are pharmaceutical compositions comprising such compounds, their preparation, and methods of treating proliferative diseases such as cancer using them in combination with chemotherapeutic agents and / or radiation. |