abstract |
Certain aza- and polyaza-naphthalenyl ketones, including certain quinolinyl and naphthyridinyl ketones, have been described as inhibitors of HIV integrase and inhibitors of HIV replication. The compound may be used as a compound or as a pharmaceutically acceptable salt or as a pharmaceutical composition component, as appropriate, in combination with other antivirals, immunomodulators, antibiotics or vaccines, to prevent or treat HIV infection and AIDS. Useful in therapy or delaying AIDS onset. Methods for treating or delaying the onset of AIDS and for preventing or treating HIV infection are also described. |