| abstract |
The present invention relates to novel NR2B selective NMDA receptor antagonistic carboxylic acid amide derivatives of the formula (I) and their racemates, enantiomers and their salts formed with acids and bases. Furthermore, an object of the present invention is to provide a pharmaceutical composition containing a compound represented by the formula (I) or a salt thereof as an active ingredient, a synthesis of a compound represented by the formula (I), and containing these compounds Chemical and pharmaceutical manufacture of medicaments and methods of treatment with an effective amount of a compound of formula (I) of the present invention by itself or as a medicament administered to the animal to be treated-including humans- It is. The novel carboxylic acid amide derivatives of formula (I) of the present invention are highly effective and selective antagonists of NMDA receptor, and many of the compounds are selective antagonists of NR2B subtype of NMDA receptor It is. |