| abstract |
Phenylacetamide compounds are described, including compounds of formula (I), or solvates, hydrates or pharmaceutically acceptable salts thereof, wherein R 3 -R 6 , R 11 , B, Y And W are described herein. The compounds of the present invention are potent inhibitors of proteases, especially trypsin-like serine proteases such as thrombin and factor Xa. Compositions are described for inhibiting platelet loss, inhibiting platelet aggregate formation, inhibiting fibrin formation, inhibiting thrombus formation, and inhibiting embolization. Other uses of the compounds of the present invention include implanting in materials used in the manufacture of devices used in blood collection, blood circulation, and blood storage, such as catheters, hemodialysis machines, blood collection syringes and tubes, transfusion vessels and stents. Or physically linked, as an anticoagulant. In addition, compounds can be detectably labeled and used for in vivo imaging of thrombus. Embedded image |