| abstract |
The present invention relates to a pharmaceutical acceptable carrier or diluent, (i) a DNA sequence encoding a site-specific recombinase, and (ii) a DNA sequence encoding a recognizing sequence of the recombinase and a heterologous polypeptide. The present invention relates to a vaccine containing a bacterium containing a containing plasmid. This recombinase stabilizes the inheritance of the plasmid, thereby preventing the ability of the bacteria to lose expression of the heterologous polypeptide. |