| abstract |
The present invention relates to novel compounds of formula (I) which are biologically active as ligands for integrin α v β 3 , wherein X is selected from the list consisting of H, acyl or naturally occurring amino acids Represents a peptide fragment having from 1 to 20 amino acids, Y represents a peptide fragment selected from the human pro-MMP-2 sequence range 466-660, and Z represents OH, NH 2 , NHA, NA Represents a peptide fragment having 1 to 20 amino acids selected from the list consisting of 2 or naturally occurring amino acids, A represents alkyl having 1 to 10 carbon atoms, and acyl represents 1 to 10 amino acids. Represents an alkanoyl having carbon atoms, the primary amino group may be provided with a conventional amino protecting group. The invention further relates to physiologically acceptable salts and solvates of these novel compounds. |