| abstract |
The present invention relates to sulfonamide derivatives having a lipophilic component and being substantially soluble. The compounds are particularly for use as pharmaceutically active compounds. The invention also relates to a pharmaceutical formulation comprising such a sulfonamide derivative. The sulfonamide derivatives are effective modulators of the JNK pathway, and they are particularly effective and selective inhibitors of JNK2 and 3. The present invention further relates to novel sulfonamide derivatives and methods for their preparation. Compounds of formula I of the present invention which are suitable pharmaceutical agents include compounds of formula I: Wherein Ar 1 or Ar 2 are, independently of one another, a substituted or unsubstituted aryl or heteroaryl, X is O or S, preferably O, and R 1 is hydrogen, or Is a C 1 -C 6 -alkyl group, or R 1 is a substituted or unsubstituted 5- or 6-membered saturated or unsaturated ring together with Ar 1 , and n is an integer of 0 to 5 And preferably 1 to 3 and most preferably 1, Y in formula I is attached to a lipophilic chain and is replaced by at least one ionizable moiety comprising at least one nitrogen atom. An unsubstituted or substituted 4-12 membered saturated cyclic or bicyclic alkyl, whereby one nitrogen atom in said ring forms a bond with the sulfonyl group of formula I, Therefore sulfone It is those represented by providing a bromide. Embedded image |