abstract |
The present invention provides novel and useful mono- and di-organic amine salts, mono- and di-amino acid salts, and mono- and di-amino acid ester salts of combretastatin A-4 phosphate prodrugs, which Increases the solubility of combretastatin A-4, readily regenerates combretastatin A-4 in vivo under normal physiological conditions, and this is physiological as a result of regeneration of combretastatin A-4 Prodrugs that are acceptable to |