abstract |
The present invention relates to a new discovery that inhibiting human CARP protein or CARP DNA / mRNA successfully treats heart disease, especially human heart failure. Accordingly, the present invention relates to pharmaceutical compositions containing substances, preferably of low molecular weight, which affect the activity of cardiac CARP. Furthermore, the present invention relates to a method for treating heart failure using a CARP inhibitory compound, a method for screening these inhibitors and the use of CARP as a diagnostic tool. |