| abstract |
The present invention discloses a method of immunization against autologous (auto) immunoglobulin E (IgE). The present invention specifically discloses a method of inducing cytotoxic T lymphocytes, particularly using nucleic acid vaccination or live vaccination and down-regulating B cell producing autologous IgE. Also disclosed are methods for inducing antibodies and IgE-specific CTK reactions in combination with methods for inducing antibodies that respond to autologous IgE. The invention also discloses specific immunogenic protein constructs, nucleic acids encoding them and various formulations, as well as means for formulating vaccines, including vectors and transformant host cells. |