| abstract |
Provide compounds of formula I wherein Y and R 1 have the meanings described herein and their pharmaceutically acceptable derivatives (including prodrugs). These compounds and derivatives include, for example, It is useful as a competitive inhibitor of a trypsin-like protease such as thrombin, or as a prodrug of the competitive inhibitor, and is therefore particularly useful in the treatment of conditions where inhibition of thrombin is required (eg, thrombosis), ie, anti-thrombotic. Useful as a coagulant. Embedded image |