| abstract |
The present invention relates to a compound of the formula (I), wherein ring C contains at least one nitrogen atom in the ring attached to Z and is optionally independently selected from O, S and N A 9- or 10-membered bicyclic heteroaromatic group containing 1 to 3 additional heteroatoms with the proviso that Ring C is not a quinazoline, quinoline or cinnoline group; Any one of G 1 , G 2 , G 3 , G 4 and G 5 is nitrogen and the other four are —CH—, or G 1 , G 2 , G 3 , G 4 and G 5 are all —CH—; Z is —O—, —NH—, —S—, —CH 2 — or a direct bond; the substituent R 1 is an indole group, an azaindole group or an indazole group. May be attached to any free carbon atom; m is an integer from 0 to 2; b is hydrogen or another meaning as defined herein; R 1 is hydrogen, hydroxy, halogeno, C 1-4 alkyl, or any other meaning as defined herein; R 2 is hydrogen, hydroxy, halogeno, cyano, nitro, trifluoromethyl, C 1-3 alkyl, C 1-3 alkoxy, C 1-3 alkylsulfanyl, —NR 3 R 4 (wherein R 3 and R 4 may be the same or different and are each hydrogen or C 1-3 alkyl) or R 5 X 1 —, wherein R 5 and X 1 are as defined herein. And salts thereof, processes for preparing such compounds, pharmaceutical compositions containing a compound of formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient, and Anti-warm-blooded animals The use of a compound of formula (I) in the manufacture of a medicament for producing tubes newborn action and / or vascular permeability reducing effect. These compounds of formula (I) and their pharmaceutically acceptable salts inhibit the action of VEGF, a valuable property in the treatment of a number of disease states, including cancer and rheumatoid arthritis. |