| abstract |
The present invention provides a compound of the formula (I) or (II) wherein R 1 is H, alkyl, alkenyl, or aryl, R 2 is H, alkyl, or aryl, and R 3 is H, R 4 ′ and R 4 -R 8 are independently R 10 , C (O) R 10 , or SO 2 R 10 , wherein R 10 is H, alkyl, alkenyl, or aryl, R 9 is, R 9a, C (O) R 9a, or a SO 2 R 9a, R 9a provides H, alkyl, alkenyl, or a compound having a a] aryl. R 9a can be unsubstituted or have one or more oxo (＝ O), OR 9b , OC (O) R 9b , OSO 2 R 9b , NHR 9b , NHC (O) R 9b and NHSO 2 R 9b Group. R 9b is H, alkyl, alkenyl, or aryl. R 9b can be unsubstituted or substituted with one or more groups such as oxo (＝ O), OR 9c , CO 2 R 9c , CO 2 R 9c and OC (O) R 9c . R 9c is H or unsubstituted or substituted alkyl, alkenyl or aryl. The present invention further provides a composition comprising at least one compound of the present invention, alone or in combination with at least one additional active agent, and a pharmaceutically acceptable carrier. The present invention further provides a method for treating a condition treatable by inhibition of vacuolar (H +)-ATPase and a method for treating cancer. Embedded image |