abstract |
Formula (I) wherein R 1 and R 2 are independently hydrogen or a substituent; R 3 is a lower alkyl having 2 to 4 carbon atoms, or cycloalkyl, cycloalkenyl, or oxygen Or a 5- to 7-membered ring that is a heterocycloalkyl having 1 heteroatom selected from sulfur; R 4 is —C (O) NHR 5 or R 6 ; R 6 Is a heteroaromatic ring linked to the amide group by a ring carbon atom and having a nitrogen adjacent to the linked ring carbon atom; and X is oxygen, sulfur, sulfonyl or carbonyl] It is a glucokinase activator useful for the treatment of diabetes. |