| abstract |
Extracellular matrix proteins (ECMs) are responsible for extracellular matrix formation, cell adhesion, cell signaling, bone mineralization, inflammatory responses, regulation of embryogenesis, tissue differentiation and / or maturation (eg, airway components in lung development). The present invention, which is believed to play a role in the regulation of branch), tissue degradation, and establishment of cell polarity, provides novel human ECM polypeptides and isolated nucleic acids comprising the coding regions of the genes encoding such polypeptides About. Vectors, host cells, antibodies, and recombinant methods for producing human ECM proteins are also provided. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating these novel human ECM protein related disorders. |