abstract |
The present invention provides novel thienopyridines, wherein such compounds of Formula 1 (where X, R 1 , R 2 , R 3 and R 4 are more fully defined herein) are represented by PTP1B , A pharmacologically useful inhibitor of protein tyrosine phosphatase (PTPase), including T cell PTP. The compounds are useful for treating type 1 diabetes, type 2 diabetes, impaired glucose tolerance, insulin resistance, obesity and other diseases. Embedded image |