| abstract |
The present invention is a method for treating bone disorders and reducing blood LDL concentration, wherein the bisphosphonate and Z are groups selected from (a), (b) or (c); R 1 is H, OH or Selected from C 1 -C 12 alkyl ethers, benzyloxy or halogen; or C 1 -C 4 halogenated ethers, including trifluoromethyl ether and trichloromethyl ether; R 2 , R 3 , R 4 , R 5 and R 6 is H, OH or its C 1 -C 12 ester or C 1 -C 12 alkyl ether, halogen, or C 1 -C 4 halogenated ether, cyano, C 1 -C 6 alkyl or trifluoromethyl When R 1 is H, R 2 is not OH; Y is R 7 and R 8 are alkyl or Or a pharmaceutically acceptable salt thereof represented by the formula (I) or (II), which is a group forming a nitrogen-containing ring which may be substituted. On how to do it. Embedded image |