| abstract |
Formula (I): Embedded image (Ar 1 is substituted or unsubstituted 2-benzothiazolyl or substituted or unsubstituted quinolinyl; X is —O—, —C (O) —, —CH (R 10 ) —, —N (R 11 ) — or —S ( O) k- ; Y is -N (R 12 ) -S (O) 2- ; R 1 is a hydrogen atom or a specified substituent; R 2 is a substituted or unsubstituted aryl; and R 3 is a halogen or (C 1 -C 8) alkoxy) Are useful for treating or preventing a condition or disease mediated by PPARγ. In particular, the compounds of the present invention modulate the function of PPARγ. The method is particularly useful for treating and / or preventing diabetes, obesity, hypercholesterolemia, rheumatoid arthritis and atherosclerosis. |