http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2004501679-A
Outgoing Links
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classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61J3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B29C48-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2009 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61J3-02 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J2-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J2-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J2-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61J3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61J3-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61J3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B29C48-285 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B29C48-025 |
filingDate | 2001-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2004-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | JP-2004501679-A |
titleOfInvention | Continuous production of pharmaceutical granules |
abstract | A one-pass continuous automatic system for producing pharmaceutical granules comprises a plurality of feeders for supplying powder and liquid, a twin screw type processor for granulation, a radio frequency or microwave based drying apparatus for drying granules and It includes at least one mill that processes the dried granules to a desired particle size. The system includes means for monitoring important process parameters online. The granules produced are compressed into tablets or filled into capsules, both having a homogeneous distribution of the active ingredient. This system produces a product with consistent properties even when the production is scaled up to produce a commercial volume of tablets. A one-pass continuous automated system for producing high-dose pharmaceutical granules from low-density active ingredients consists of multiple feeders that supply powders and liquids, twin-screw processors for granulation, radio-frequency or micro- Includes a wave-based drying device and at least one mill that processes the dried granules to a desired particle size. This system produces a product with consistent properties even when scaling up production to produce commercial volume tablets. The twin screw processor has first and second transport elements, and has a mixing element disposed between the transport devices, wherein the second transport element has at least a pitch less than at least one pitch of the first transport elements. It has one pitch. The system also allows for optimization of a number of other design parameters. These parameters include the position and feed rate of the side stuffer and liquid feeder, the rotational speed of the granulator itself, and the final granule size. This system is particularly suitable for producing granules of nelfinavir mesylate with excipients containing calcium silicate, for high dose products. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2019515792-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2020110799-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009533320-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014073484-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015085225-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2005524670-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015038115-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009529516-A |
priorityDate | 2000-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 457.