| abstract |
The present invention relates to novel compounds, novel compositions, methods of using them, and methods of making them, wherein such compounds are pharmaceutically useful inhibitors of protein tyrosine phosphatases (PTPases, PTPs), for example, PTP1B, TC-PTP, CD45, SHP-1, SHP-2, PTPα, PTPε, PTPμ, PTPδ, PTPσ, PTPζ, PTPβ, PTPD1, PTPD2, PTPH1, PTP-MEG1, PTP-LAR , And HePTP. These compounds have application in the management and treatment of a wide range of diseases, autoimmune diseases, acute and chronic inflammation, osteoporosis, various types of cancer and malignancies, and type I and type II diabetes. |