| abstract |
A method for determining the structure of a biomolecule target and the site and nature of the interaction between a ligand and the biomolecule target is provided. Kind Code: A1 A method for determining the structure of a biomolecule target such as a nucleic acid using mass spectrometry, comprising not only the primary sequence structure of a nucleic acid target but also mismatched base pairs, loops, bulges, entanglements ( kink), and information on the secondary and tertiary structure of nucleic acids, RNA and DNA, including system structures. This is consistent with one embodiment, in which these hybrid RNA / DNA nucleic acids are selectively incorporated in a mass spectrometer after incorporation of deoxynucleotide residues or other modified residues into oligoribonucleotides at specific sites. This can be achieved by cutting. [Selection diagram] None |