| abstract |
PROBLEM TO BE SOLVED: To provide a p38 MAP kinase inhibitor comprising a 4-imidazolin-2-one compound. SOLUTION: The formula [I] [Wherein G 1 is an alkyl optionally substituted with a halogen atom or alkoxy, or a compound represented by the formula: (Wherein, ring B represents a benzene ring or the like which may be substituted, W represents a single bond or C 1 -C 4 alkylene which may be substituted with 1 or 2 alkyls). A group, Q 1 and Q 2 are hydrogen, halogen or alkyl, n is 0 to 4, R 1 is hydrogen, alkyl, cycloalkyl, phenyl and the like; Z 1 , Z 2 , Z 3 and Z 4 are CH and N, G 2 represents hydrogen, —NR 3 R 4 , —OR 5 and the like, and R 3 to R 5 represent hydrogen, alkyl, alkenyl, alkynyl and the like. And p38 MAP kinase inhibitor. [Selection diagram] None |