| abstract |
PROBLEM TO BE SOLVED: To develop a technology for controlling the amount of free fatty acids and cholesterol in a living body, and to further improve the condition of the skin (prevention / improvement of skin roughness, prevention / prevention of spots / wrinkles, etc.) and high fat using the technology. Provide technology applicable to the treatment of blood sickness, etc. SOLUTION: A free fatty acid and cholesterol or a derivative thereof act as substrates without mediating the action of a coenzyme, do not act on a fatty acid-CoA complex, and catalyze a cholesterol ester formation (acyl group transfer) reaction. A new cholesterol esterification enzyme. The enzyme has a molecular weight of 40 kDa to 45 kDa (gel filtration method), an action pH of 3.0 to 7.0, an optimum pH of 4.0 to 5.0, and acts in a wide range of 4 to 60 ° C., and has an optimum action temperature of 20 to 40 ° C. ５０50 ° C. [Selection diagram] FIG. |