http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2004305081-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9aa697692734f1f3df89fd278db976cb |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 |
| filingDate | 2003-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0aa5c1f60bee56384cc9d586368adfa4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_843d173070db42359418a74a7e536871 |
| publicationDate | 2004-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2004305081-A |
| titleOfInvention | Transformed cell expressing cytochrome P450 and reporter, complex culture system containing the cell, and method for measuring endocrine disrupting action using the cell |
| abstract | An object of the present invention is to provide a method for efficiently measuring an endocrine disrupting effect of a chemical substance through an absorption / metabolism process in a living body, and a transformed cell usable in the method. Kind Code: A1 Abstract: The present invention is directed to a downstream of a transcription control region containing at least one cytochrome P450 expression gene, at least one hormone receptor expression gene, and a hormone response element to which at least one expressed hormone receptor binds. Provided is a transformed cell that expresses a cytochrome P450 and a reporter, wherein the linked reporter expression gene has been introduced into a cell derived from a mammal. The cells allow for continuous measurement of metabolism of chemicals and endocrine disrupting effects via metabolic processes in the same cell. Further, the combined culture system of the obtained cell culture system and cells having a function of absorbing a chemical substance enables continuous and efficient measurement of the endocrine disrupting action via a process of absorbing and metabolizing a chemical substance. [Selection diagram] None |
| priorityDate | 2003-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 642.