| abstract |
PROBLEM TO BE SOLVED: To provide dendritic cells (DC) induced by culture conditions containing both IL-10 and TGF-β or those obtained by further adding inflammatory stimuli (for example, TNF-α, LPS, etc.) to the DC as necessary. To provide therapeutic agents for transplant rejection, graft-versus-host disease, autoimmune disease or allergic disease, to which a target disease-related antigen is added. A method for inducing human immunoregulatory dendritic cells by culturing human dendritic cells or progenitor cells thereof in vitro with cytokines containing at least IL-10 and TGF-β, and obtained by the method Human immunoregulatory dendritic cells and pharmaceutical compositions comprising the human immunoregulatory dendritic cells. [Selection figure] None |