| abstract |
PROBLEM TO BE SOLVED: To provide a novel, biologically active, recombinantly produced BPI (rBPI) protein and a protein fragment which inhibits the formation of dimers and cysteine adducts and gives a product which is very useful for pharmaceutical use Novel DNA sequences encoding the products, rBPI products and analogs, plasmid vectors containing the DNA, host cells stably transformed or transformed with the plasmid, recombinant preparation methods, stable drug compositions, and To provide a method of treatment. [Solution] The present invention relates to DNA encoding a biologically active fragment of a bactericidal / permeability-improved protein having a leucine residue at position 193 as the carboxy terminal residue. [Selection diagram] None |