| abstract |
[Problem] To provide a compound for imaging diagnostic probe of a disease in which amyloid β protein is accumulated, a composition containing the same, a kit, a method for staining senile plaques, and a pharmaceutical composition for preventing and treating diseases caused by protein β sheet structure. . Kind Code: A1 Formulas I (a) or I (b) for diagnostic imaging probes: [Wherein R 1 , R 2 and R 3 independently represent hydrogen, halogen, OH, COOH, SO 3 H, NH 2 , NO 2 , alkyl having 1 to 4 carbons, O-carbon having 1 to 4 R 4 and R 5 are independently hydrogen or alkyl having 1 to 4 carbons, X is oxygen, sulfur or NR 6 , and R 6 is hydrogen or 1 to 4 carbons Y is nitrogen or CR 7 , R 7 is hydrogen or alkyl having 1 to 4 carbons, Z is nitrogen or CR 8 , R 8 is hydrogen or 1 to 4 carbons And n is an integer from 0 to 4. Or a salt or solvate thereof. [Selection diagram] None |