| abstract |
The present invention provides a compound effective for treating fibrosis or sclerosis, and further discloses a method for skin reconstruction or wound treatment and an artificial connective tissue. Further disclosed is a cell-based method for the identification and isolation of compounds that modulate the activity or expression of MMP and its use in methods of manufacturing anti-cancer drugs and anti-cancer drugs that support wound treatment. An effective amount of PIII snake venom Zn-metalloproteinase (SVMP), or a fragment, peptide, derivative, homologue, or mimetic thereof, or a nucleic acid encoding any one of these compounds is administered. A method of inducing expression of matrix metalloproteinase (MMP) in fibroblasts. [Selection figure] None |