| abstract |
[Object] To elucidate the regulatory mechanism of a Na / Pi type II transporter and to provide a regulator of a type II transporter. The present invention also provides a method for screening a substance that acts on a factor that regulates the type II transporter expression. SOLUTION: FGF23 and FGF23 mutants (R176Q, R179Q, etc.) suppress the type II transporter expression, It was found that acid reabsorption was reduced. The present invention provides a type II Na / Pi symporter expression regulator comprising FGF23 and FGF23 mutant. The present invention also provides a method of screening for a substance that can interact with FGF23 or a mutant thereof. [Selection diagram] None |