| abstract |
PROBLEM TO BE SOLVED: To provide a substituted benzoylguanidine compound useful for treating cardiovascular diseases such as arrhythmia and other treatments. SOLUTION: Formula I Embedded image Wherein R (1) and R (2) are H, Hal, (cyclo) alkyl, N 3 , CN or OH, alkyloxy, phenyl, phenoxy or benzoyl, and R (3) is H ) And pharmaceutically acceptable salts of these compounds, except for the compounds benzoylguanidine 4-chlorobenzoylguanidine, 3,4-dichlorobenzoylguanidine, and 3- or 4-methylbenzoylguanidine. The substituted benzoylguanidine shown. [Selection diagram] None |