| abstract |
The present invention provides a pharmaceutical composition comprising an aggrecanase selection inhibitor for treating osteoarthritis. Kind Code: A1 Formula I: [X is carbon or nitrogen; at least one of R 1 and R 2 is methyl; R 3 and R 4 are hydrogen, hydroxy, methyl and the like; R 5 and R 6 are independent substituents; R 7 and R 8 is hydrogen or the like]. [Selection diagram] None |