abstract |
Kind Code: A1 A knockout in which the genomic gene of a fat accumulation promoting protein is partially or entirely destroyed to change the blood level and / or expression level of the fat accumulation promoting protein itself, or to knock out the fat accumulation promoting protein. Provided is the development of a homologous recombination method for producing a non-human animal simply and quickly, and a knockout non-human animal produced using the homologous recombination method. Kind Code: A1 All or one allele in a diploid of a genomic gene of a fat accumulation promoting protein, which is an individual of a knockout non-human animal or a progeny animal or a part thereof, and has a molecular weight of about 6,000 or more, has a function thereof. A non-human animal or a part thereof, wherein the non-human animal is replaced with a deletion mutant gene or all or one allele in a diploid of the genomic gene is destroyed so as to lose its function, And a method for evaluating the ability to control glycolipid metabolism using the non-human animal or a part thereof can be provided. [Selection diagram] None |