abstract |
An object of the present invention is to provide a composition which can be used for a surgical instrument, an implantable invasive device, or the like, and which has (1) no bactericidal activity and (2) endotoxin neutralizing activity. Kind Code: A1 A neutrophilic granule protein, BPI protein, is coated on a surface of a surgical instrument such as a catheter or a staple, or an implantable invasive device such as a surgical implant by coating the BPI protein with an endotoxin. To prevent or treat death from endotoxin caused by Gram-negative bacterial infection. [Selection diagram] None |