| abstract |
The present invention relates to a phosphoric acid or phosphonic acid derivative having excellent immunosuppressive activity, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable ester thereof. The general formula (Ip) Embedded image [Wherein, R 1 , R 2 : H, etc .; R 3 , Ra 3 : H, a protecting group for a phosphate group; R 4 : H, a lower alkyl group, etc .; n: 1 to 6; X: an ethylene group, etc.] Y: single bond, C 1 -C 10 alkylene group, etc .; Z: oxygen atom, methylene group; R 5 : H, cycloalkyl group, aryl group, etc .; R 6 , R 7 : H, halogen atom, etc .; When 5 is a hydrogen atom, Y represents a substituted C 1 -C 10 alkylene group or the like. Or a pharmacologically acceptable salt thereof or a pharmacologically acceptable ester thereof. [Selection diagram] None. |