| abstract |
A present invention provides novel IP 3 receptor binding protein comprising an effective indicator for the detection and quantification of IP 3, as well as detection and / or quantification method of IP 3 using the same. An IP 3 receptor binding proteins, in particular IP 3 interacts with the receptor, and the interaction is controlled by the IP 3, identified a novel IP 3 receptor binding protein IRBIT. IRBIT has the characteristic that the IP 3 of physiological concentrations can be dissociated from the IP 3 receptor. By the characteristic, IRBIT is useful as an indicator to detect IP 3 by FRET method or the like. [Selection diagram] None |