| abstract |
PROBLEM TO BE SOLVED: To provide a synthetic catalytic oligonucleotide structure suitable for cleaving a target sequence of a nucleic acid. A synthetic catalytic oligonucleotide capable of cleaving a target sequence of ribonucleic acid, having the following general structural formula (II): Embedded image In at least one of the nucleotides N 2 , N 3 , N 5 , N 6 , N 7 , N 9 , N 13 and N 14 in the formula (II), the R group of the formula (I) is other than hydrogen. Wherein at the nucleotides N 1 , N 4 , N 8 , N 10 , N 11 and N 12 in formula (II) the R group of formula (I) is hydrogen and at the free 3 ′ end of the oligonucleotide An oligonucleotide characterized by the presence of 3'-deoxyribonucleotides and / or 3'-O-alkyl ribonucleotides. |