| abstract |
SOLUTION: General formula (1) Embedded image [Wherein, R 1 , R 2 and R 3 are a C 1-6 alkyl group or the like; R 4 is a hydrogen atom or the like; R 5 and R 6 are the same or different and are a hydrogen atom, a C 1-6 alkyl group, C 1-6 alkoxy group, a halogen atom or the like; X is -NH -, - O -, - CH 2 - be like; Y is an -NH- or the like; Z is -CO-, etc. A is an aryl group, a heteroaryl group or the like], or a pharmaceutically acceptable salt thereof. [Effect] The compound (1) of the present invention and a pharmaceutically acceptable salt thereof are useful as a therapeutic drug for fibrosis by specifically acting on Edg-5. [Selection diagram] None |