| abstract |
To provide a mechanism for improving cardiac function after myocardial infarction, mobilizing stem cells to myocardium damaged by cytokines, and promoting differentiation from cells to cardiomyocytes. A composition comprising a gp130 ligand (eg, LIF). Preferably, the gp130 ligand comprises the sequence shown in SEQ ID NO: 2 or 4, or one or more substitution additions or deletions. The gp130 ligand can be provided in nucleic acid form or polypeptide form. [Selection figure] None |