abstract |
A method for screening a tumor antigen capable of inducing an anti-tumor immune response capable of immunotherapy against cancer, such as exhibiting an antitumor effect even on a human distant tumor such as a metastatic tumor, and a tumor obtained by the screening method Providing antigens and genes encoding them. A herpes simplex virus or herpes simplex virus glycoprotein is administered directly to tumor tissue to induce tumor-specific cytotoxic T lymphocytes (CTLs), and the induced tumor-specific CTLs, And / or using a testis-derived cDNA library or a tumor-specific IgG-derived serum containing such induced tumor-specific IgG, and a tumor and / or testis-derived cDNA library. Screen for tumor antigen peptides. |