| abstract |
PROBLEM TO BE SOLVED: To provide a compound which has an excellent β-secretase inhibitory action and Aβ production / secretion / aggregation inhibitory action, and which is sufficiently satisfactory as a pharmaceutical. SOLUTION: The formula (I) Embedded image In the formulas, A ring aromatic ring group optionally having a substituent, R 1 is each aryl -C 0-6 alkyl optionally having substituent, heteroaryl -C 0-6 alkyl, C 1-6 alkyl, etc., R 2 is hydrogen, each aryl -C 0-6 alkyl optionally having substituent, heteroaryl -C 0-6 etc., R 3 are each a substituent X and Y may be oxygen, etc., and the bonding site shown by a solid line and a dashed line may be a single bond or an aryl-C 0-6 alkyl, heteroaryl-C 0-6 alkyl, C 2-10 alkyl, etc. A double bond], and a β-secretase inhibitor containing the compound. [Selection diagram] None |