abstract |
A nicotinamide derivative useful for treating diseases such as asthma, adult respiratory disease syndrome, atopic dermatitis, rheumatoid arthritis, and depression. A compound of the following general formula or a pharmaceutically acceptable salt: [The dashed line represents a double bond, m, n, o, p, q, r, and t are 0 to 4, A is oxygen, NH, S, B is oxygen, NH, D is oxygen, NR 9 , E is CH 2 , O, NH, etc., R 1 is hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, etc., R 2 , R 3 , R 4 are independently hydrogen, hydroxy, R 5 is a heterocyclic group containing 1 to 4 heteroatoms independently selected from oxygen, sulfur, nitrogen and NR 9 , R 6 , R 7 and R 8 are each independently hydrogen , Halo, cyano, nitro, etc.] [Selection diagram] None |