| abstract |
An estradiol and / or a derivative thereof, which is an active ingredient contained in a pressure-sensitive adhesive layer, has good solubility in a pressure-sensitive adhesive layer, does not adsorb the active ingredient in a support, and further has a patch. Provided is an external patch that can follow the uneven surface of the skin itself or the movement of the skin. In an external patch comprising a support and a pressure-sensitive adhesive layer, the pressure-sensitive adhesive layer comprises an acrylic pressure-sensitive adhesive containing 0.01 to 1% by weight of an isocyanate-based cross-linking agent as an essential component. An external patch containing estradiol, comprising estradiol and / or a derivative thereof, crotamiton 0.1 to 10% by weight, and oleic acid 0.1 to 10% by weight. [Selection] Fig. 2 |