| abstract |
The present invention has a serine protease inhibitory activity, and has precoagulation, hypertension, heart failure, ischemic peripheral circulation disorder, myocardial ischemia, venous dysfunction, progression of heart failure after myocardial infarction, diabetic nephropathy, nephritis, arteriosclerosis , Hyperaldosteronism, scleroderma, glomerulosclerosis, renal failure, Alzheimer's disease, memory deficiency, depression, sensory dysfunction, anxiety, nervous symptoms, discomfort mental state, glaucoma, ocular hypertension, restenosis after PTCA, Provided are compounds useful as therapeutic agents for asthma, rhinitis, or allergic diseases. SOLUTION: Expression (1) Embedded image (Wherein, R represents a group represented by the formula: —CHO or —CH 2 OH) Or a salt thereof. [Selection diagram] None. |