| abstract |
[Object] To provide a quinoline compound having a melanin-concentrating hormone antagonistic activity and useful as an agent for preventing and treating obesity. SOLUTION: The formula: [Wherein, Ar represents a cyclic group which may have a substituent; X represents a bond or to 1 -C main chain shows the spacer 6; R 1 and R 2 are either the same or different and may have a hydrogen atom or a substituent hydrocarbon group, and R 1 R 2 may form a nitrogen-containing heterocyclic ring which may have a substituent together with an adjacent nitrogen atom; Y represents a divalent hydrocarbon group which may have a substituent (excluding CO); R 3 represents a hydrogen atom or a hydrocarbon group which may have a substituent; Ring A and ring B may further have a substituent. When ring B has a further substituent, the substituent may be bonded to R 1 to form a ring. Or a salt thereof, or a prodrug thereof. [Selection diagram] None |