| abstract |
A novel gene involved in multidrug resistance in cancer and a protein thereof are searched and provided, the function of the gene and the protein is elucidated, a test method for the gene and an antibody against the protein are provided, A method for testing and diagnosing cancer using the gene and antibody is provided. A novel protein (RB1CC1) present in the nucleus of a human or animal cell and having a function capable of inducing transcription factor function and / or expression of a retinoblastoma-1 gene (RB1 gene) or a gene product thereof, or The polypeptide and its gene were found. Determine the amino acid sequence and cDNA sequence, amplify and detect the gene with primers that hybridize with the new gene, examine the expression and mutation of the new gene, find the relationship with the growth of cancer cells, and test for cancer Then, an antibody against the new protein was prepared, and by detecting the new protein with the antibody, the relationship between the new protein and the growth of cancer cells was found, and cancer was examined. |