abstract |
The present invention provides the identification of orphan G-protein coupled receptor MRGX2 (and variants thereof) as a receptor for neuropeptides, and the use of neuropeptides (and structurally related molecules) as modulators of MRGX2. . The present invention provides a method of screening for a modulator of a novel neuropeptide receptor: (a) a sample of the receptor MRGX2, cortistatin, somatostatin, Bam13-22, α-MSH, neuropeptide FF, dynorphin A or Contacting a ligand selected from substance P or an analog or mimetic of any one of these neuropeptides; (b) a similar sample of the receptor MRGX2 or a membrane prepared from cells containing said sample; Contacting both the ligand used in (a) and the test compound or a mixture of test compounds; (c) the steps of (a) and (b) to determine whether the binding of the ligand used is affected. Compare the results. [Selection diagram] None |