| abstract |
A drug useful for preventing and treating inflammatory diseases and malignant tumors by identifying a novel class 2 cytokine receptor (SJ2368) and its gene, and a method for screening the same. The present invention provides a gene, PLOD2, encoding telopeptide lysyl hydroxylase (TLH), and a method and composition for preparing a collagen material having various biodegradation rates. Also provided are methods for reducing the ratio of hydroxyallysine crosslinks to allicin crosslinks in the course of fibrosis, and compositions and methods for screening the same, and methods for diagnosing and / or monitoring the course of fibrosis. [Selection] Fig. 6 |