| abstract |
An object of the present invention is to provide a novel thiol derivative which has a matrix metalloprotease inhibitory activity and is useful as a medicine, particularly as a therapeutic agent for osteoarthritis and rheumatoid arthritis. The formula [I] [Wherein, ring A represents an optionally substituted aromatic heterocyclic ring, ring B represents an optionally substituted homocyclic or heterocyclic ring, R 1 represents a hydrogen atom, an optionally substituted hydrocarbon A group, an acyl group, an optionally substituted heterocyclic group or SR 2 , X represents an optionally substituted divalent C 1-3 aliphatic hydrocarbon group, and Y represents an optionally substituted Hydrogen group, halogen atom, carboxyl group, acyl group, optionally substituted hydroxy group, optionally substituted amino group, SR 3 , oxo group, thioxo group, optionally substituted imino group, nitro group Or q represents a cyano group, and q represents an integer of 0 to 5. Or a salt thereof. [Selection diagram] None |