| abstract |
The present invention provides a therapeutic agent having an osteoblast-promoting action required for metabolic bone diseases such as osteoporosis. A nitrogen-containing heterocyclic compound represented by the following formula 1 or a pharmaceutically acceptable salt thereof. (X 1 and X 2 are N or CR 5 , at least one is N, Y is N or Y is CR 6 when both X 1 and X 2 are N, and R 1 is —NRaRb, aryl, cycloalkyl, etc. also Ra and Rb are H, CO- lower alkyl and the like, E is a single bond, C 1-3 alkylene, vinylene (-C = C-), etc., R 2 represents aryl, heteroaryl, etc.). That is, 3,6-disubstituted 1,2,2, such as 6-azocan-1-yl-3 (6-methoxypyridin-2-yl) -1,2,4-triazolo [4,3-b] pyridazine. 4-triazolo [4,3-b] pyridazine or a pharmaceutically acceptable salt thereof. [Selection diagram] None |