| abstract |
(57) [Summary]nThe present invention relates to a novel biopolymer consisting of (a) a cross-linking agent activated by an activating substance and dissolved in an aqueous solution, and (b) a three-dimensional cross-linked mixture of a recombinant protein, ie, polyubiquitin. The novel biopolymers are based on the crosslinking of ubiquitin (monomer and / or polymer) and crosslinker in aqueous solution in appropriate proportions, preferably based on bifunctional polyethylene oxide or polyethylene glycol of various molecular weights (molecular weight 2000 to 35000 kDa). Things. Because many ubiquitin units and crosslinkers can be varied in both length and ratio, new biopolymers are provided in a wide range of formulations. The novel hydrogel is also biodegraded by certain proteases, but is resistant to a wide range of other proteases. |